Breakthrough Studies in Stem Cell & Exosome Therapy
Explore a curated selection of peer-reviewed studies from leading researchers and medical experts at the forefront of regenerative medicine. These publications highlight groundbreaking advancements in stem cell therapy, tissue engineering, and gene therapies, offering valuable insights into the evolving landscape of innovative healthcare solutions.
Osteoarthritis (OA)
Discover how mesenchymal stem cells (MSCs) are advancing regenerative medicine, specifically in the areas of articular cartilage and intervertebral disc repair.
Autism
Autologous Cord Blood Infusions Prove Safe and Feasible for Young Children with Autism Spectrum Disorder: Findings from a Single-Center Phase I Open-Label Trial
Rheumatoid Arthritis/ Polymyalgia Rheumatica (OA/PMR)
Autologous Stromal Vascular Fraction Cells: A Potential Tool for Promoting Tolerance in Rheumatic Diseases.
Post Cancer Chemotherapy
Adult Mesenchymal Stem Cells in the Treatment of Radiation Injury
Anti-Aging
Cellular Reprogramming-Based Strategies for Anti-Aging
Osteoarthritic Joint Pain
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In Conjunction with Surgical Treatment
Fortier LA, et al. (2010) Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in an equine model. Link
Milano G, et al. (2010) The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model. Link
Buda R, et al. (2015) One-step bone marrow-derived cell transplantation in talar osteochondral lesions: mid-term results. Link
Meniscus or Ligament Injuries
Meniscus or Ligament Injuries
Foster TE, et al. (2009) Platelet-rich plasma: from basic science to clinical application. Link
Murray MM, et al. (2009) Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen–platelet-rich plasma scaffold. Link
Braun HJ, et al. (2013) The Use of PRP in ligament and meniscal healing. Link
Yu H, et al. (2015) Meniscus repair using mesenchymal stem cells – a comprehensive review. Link
Cook JL, et al. (2016) Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency. Link
Muscle and Tendon InjuriesLateral Epicondylitis
Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow-up. Link
Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Link
Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Link
Patellar Tendonitis
Cervellin M, et al. (2012) Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: a randomized, controlled clinical study. Link
Di Matteo B, et al. (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review. Link
Pascual-Garrido C, et al. (2012) Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year followup. Link
Rotator Cuff Tears
Randelli P, et al. (2011) Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. Link
Hernigou P, et al. (2014) Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Link
Achilles Tendinopathy
Fractures
Galasso O, et al. (2008) Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions. Link
Bursitis
Sampson S, et al. (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Link
Cosmetic Surgery
Man D, et al. (2001) The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Link
Cervelli V, et al. (2009) Application of platelet-rich plasma in plastic surgery: clinical and in-vitro evaluation. Link
Redaelli A, et al. (2010) Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. Link
Sclafani AP, and SA McCormick. (2012) Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Link
Lee JW, et al. (2011) The Efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: A Simultaneous Split-Face Trial. Link
Cho JM, et al. (2011) Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. Link
Shin MK, et al. (2012) Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Link
Spine
Pettine K, et al. (2015) Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months. Link
Pettine K, et al. (2016) Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up. Link
Monfett M, et al. (2016) Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. Link
Wound Care
Hom DB, et al. (2007) The healing effects of autologous platelet gel on acute human skins wounds. Link
Driver VR, et al. (2006) A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Link
Kazakos K, et al. (2009) The use of autologous PRP gel as an aid in the management of trauma wounds. Link
Carter MJ, et al. (2011) Use of platelet-rich plasma gel on wound healing: a systematic review and meta-analysis. Link
Saad Setta, H, et al. (2011) Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study. Link
Dabiri G, et al. (2013) The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds. Link
Oral and Maxillofacial Surgery
Marx RE. Platelet-rich plasma: evidence to support its use. Link
Sammartino G, et al. (2005) Use of autologous platelet-rich plasma in periodontal defect treatment after extraction of impacted mandibular third molars. Link
Bajaj P, et al. (2013) Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. Link
Peripheral Vascular Disease
Tateishi-Yuyama E, et al. (2002) Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone-marrow cells: a pilot study and a randomized controlled trial. Link
Bartsch T, et al. (2007) Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study). Link
Amann B, et al. (2009) Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease. Link
Fadnini GP, et al. (2010) Autologous stem cell therapy for peripheral arterial disease: Meta-analysis and systemic review of the literature. Link
Molavi B, et al. (2016) Safety and Efficacy of Repeated Bone Marrow Mononuclear Cell Therapy in Patients with Critical Limb Ischemia in a Pilot Randomized Controlled Trial. Link